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Anemia of Chronic Disease (ACD), or the anemia of inflammation, is a mild to moderate anemia accompanying infectious, inflammatory, or neoplastic disease that is characterized by abundant reticuloendothelial iron unavailable to bone marrow erythroid precursors.
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Differences found between the biosimilar and the reference product need to be justified in the application dossier.
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Adults with cancer can experience any of the physical and psychological problems that produce cognitive impairment in adults without cancer, such as renal failure, liver failure, sedation from analgesics, drug interactions, sepsis, hypoxia, and cerebrovascular problems.
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The hormone is also used in people with anemia due to AZT and other treatments of AIDS, transfusion dependent myelodysplasia, chemotherapy induced anemia and anemia in surgical settings.
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Treatment usually involves taking a daily oral folic acid supplement for several months, as well as increasing intake of foods rich in folate and vitamin B12.
At present, blood transfusions are currently the only approved treatment option; however these lead to iron overload, which is associated with significant morbidity and mortality.
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